Abstract: In order to help freshmen adapt to the learning style of university, cultivate their active learning ability, and stimulate their interest in scientific research, the freshman seminar ″How much do you know about the world of microorganisms?″ was designed in Tianjin Medical University. The curriculum has been implemented since 2019 and four rounds have been opened by 2023, a total of 48 students have enrolled in the course. This study introduced the design and implementation of the curriculum, and investigated the effectiveness of the curriculum. There were 46 students participated the investigation. The results showed that 44(95.7％) of the students thought that the course was helpful for them to adapt to the study of the university, 43(93.5％) of them believed that the course was helpful to understand the basic knowledge and the scientific frontiers of microbiology, 41(89.1％) of the students acknowledged that their active learning ability and innovation consciousness have been improved, and 38(82.6％) of them believed that the course stimulated their interest in scientific research.In the four rounds of the curriculum, the scores of the students were (94.36±2.59),(93.62±2.65), (93.81±2.71), and (95.08±2.01), respectively. Microbiology freshmen seminar is helpful for freshmen to adapt to the university learning style, helps them understand the basic knowledge and scientific advances of microbiology, cultivates their active learning ability, and stimulates their interest in scientific research.

Key words: Microbiology, Freshman, Seminar, Course construction