Objective Analyzing the quantity and geographic distribution of colleges offering undergraduate clinical medicine program in China and so to provide research basis for the development of national strategy for specialty establishment. Methods Using the data from the Ministry of Education in 2018, the distribution of colleges in regions were analyzed by descriptive statistics. Using the Theil index to explore the source of difference. Results Up to 2018, there were 181 colleges offering undergraduate clinical medicine program in China, accounting for 14.54% of the total undergraduate colleges and 51.28% (20/39)of the 985 Project colleges offering undergraduate clinical medicine program, while in other undergraduate colleges the percentage is only 13.24(150/1133). On average, each province has 5.84 colleges offering undergraduate clinical medicine program. The number of colleges offering undergraduate clinical medicine program for every 10 million populations and every 100 thousand square kilometers is 1.30 and 1.88. The contribution rate of the Theil index in the interior region was 81.58%. Conclusions The proportion of high-level colleges offering undergraduate clinical medicine program is much higher than other undergraduate colleges. The level and number of colleges offering undergraduate clinical medicine program vary greatly among regions. Setting the undergraduate clinical medicine program must to consider the factors such as the absolute number and relative number of colleges offering undergraduate clinical medicine program, the academic level of colleges and the strength of clinical medicine discipline.