Objective To explore the moral education effects and its relationship with college students' learning commitment. Methods In 2017, 2 215 undergraduates in a medical college were investigated by online Chinese college student survey (CCSS), and the following index scores were statistically analyzed: the index of moral education and the 5 dimension indicators of college students' learning commitment. Results From grade one to grade four, the index of “establish the outlook on life and values of the moral education” scored respectively (57.13±26.95),(60.35±26.32),(62.20±26.13),(63.84±25.67), “teamwork spirit of the moral education” scored respectively (62.35±25.57),(66.07±23.51),(64.75±24.65),(66.00±24.08), “critical spirit of the moral education” scored respectively (55.16±25.69),(59.88±25.56),(60.13±25.48),(59.75±25.78), “spirit of innovation” scored respectively (50.22±27.23),(56.23±26.39),(58.03±25.92),(57.06±26.14), and there were significant differences between different grades (all P＜0.01). The scores of academic challenge, active and cooperative learning, student-faculty interaction, enriching educational experiences, supportive campus environment were (46.92±12.40), (51.64±18.13), (37.23±20.13), (42.31±17.49) and (62.12±17.13) respectively. The results of level analysis showed that the five dimensions of learning engagement were the influencing factors for the effect of moral education. Conclusions College study is conducive to the growth of students' “morality”, and the degree of college students' learning engagement will have an impact on the effect of moral education.