This thesis thoroughly introduces the method of PBL in University of Delaware. Its PBL has broken the procedural and separately displayed model. The design of PBL focuses on social reality and complexity and stresses learners' attitudes, integrity of multiple subjects, problem-solving ability and various teaching goals. Though there are various PBL presentations, the core of PBL teaching design lies in real social problems, learning initiative, group study and inquiring learning. On this basis, taking the PBL teaching mode in classic literature of Chinese medicine at Shanghai University of Traditional Chinese Medicine as an example, this paper puts forward some suggestions on the teaching reform of medicine colleges and universities in China: We can get some hints from its experiences.Teaching reform of Traditional Chinese Medicine(TCM) should guide students to develop in a comprehensive way and require teachers to enhance their academic ability from various aspects. Instead of combining different disciplines, the PBL reform of TCM should piece together PBL in one discipline with module PBL and make the design and implementation of PBL featured by different phases and levels.