Basic medical comprehensive experiments play a significant role in medical education, serving as a crucial component in cultivating students′ practical abilities, scientific research thinking, and innovative capabilities. However, current basic medical experimental teaching still faces issues such as monotonous content, insufficient comprehensiveness, and disconnection from clinical practice. To address these problems, the School of Basic Medical Sciences at Wuhan University initiated a reform in 2023. Based on preliminary research, the school integrated multi-source achievements, including undergraduate scientific innovation projects, faculty research projects, and relevant literature in the field of basic medical sciences. Experimental achievements from disciplines such as morphology, functional science, and molecular biology were transformed into teaching content for basic medical comprehensive experiments. By combining these with existing experimental teaching materials, a research achievement-driven teaching model for basic medical comprehensive experiments was established. This model promotes the comprehensive integration of basic medical experimental courses, ensures that the curriculum keeps pace with cutting-edge advancements in the field, and fosters students′ interest in scientific research and research-oriented thinking.
Cong Jianchao
,
Xu Shengnan
,
Wu Junzhu
,
Li Ke
,
Wang Hui
,
Liu Jun
,
Liu Yanhong
. Translational research on the teaching and learning of comprehensive basic medical laboratory based on the results of multi-source scientific research[J]. Chinese Journal of Medical Education, 2025
, 45(7)
: 514
-518
.
DOI: 10.3760/cma.j.cn115259-20240318-00271
[1] 王见之, 张志刚, 严钰锋. 构建形态、功能相结合的整合式基础医学实验教学新体系[J].基础医学教育,2018,20(1):32-33. DOI:10.13754/j.issn2095-1450.2018.01.10.
[2] 赵燕燕, 武变瑛, 杜光玲, 等. 综合性大学基础医学实验教学体系的改革与构建[J].医学研究与教育,2009,26(2):99-102. DOI:10.3969/j.issn.1674-490X.2009.02.041.
[3] 孙晓明, 苏超, 孙亚楠, 等. 综合设计性实验教学培养学生创新能力的探索[J].实验室科学,2020,23(4):128-130,134. DOI:10.3969/j.issn.1672-4305.2020.04.033.
[4] 金晶, 高小惠, 徐薇薇. 大学生创新训练项目质量管理体系的建立[J].基础医学与临床, 2015, 35(3): 432-434. DOI:10.16352/j.issn.1001-6325.2015.03.034.
[5] 扈旻, 邓北星, 马晓红, 等. 科研成果转化为实验教学内容的探索与实践[J].实验技术与管理,2012,29(10):21-23. DOI:10.3969/j.issn.1002-4956.2012.10.007.
[6] 刘德宝, 李春亮. 科研成果向创新性实验转化的研究与实践[J].实验室科学,2021,24(1):237-240. DOI:10.3969/j.issn.1672-4305.2021.01.064.
[7] 刘金库, 盛潇潇, 张敏, 等. 科研成果向实验教学一线转化可借鉴实施模式探索[J].实验室研究与探索,2021,40(11):160-163. DOI:10.19927/j.cnki.syyt.2021.11.033.
[8] Brooks D, Barr LC, Wiscombe S, et al. Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation[J].Eur Respir J, 2020,56(1):1901298. DOI:10.1183/13993003.01298-2019.
[9] Domscheit H, Hegeman MA, Carvalho N, et al. Molecular dynamics of lipopolysaccharide-induced lung injury in rodents[J].Front Physiol, 2020,11:36. DOI:10.3389/fphys.2020.00036.
[10] Wepler M, Preuss JM, Merz T, et al. Impaired glucocorticoid receptor dimerization aggravates LPS-induced circulatory and pulmonary dysfunction[J].Front Immunol, 2019,10:3152. DOI:10.3389/fimmu.2019.03152.
[11] Dutra Silva J, Su Y, Calfee CS, et al. Mesenchymal stromal cell extracellular vesicles rescue mitochondrial dysfunction and improve barrier integrity in clinically relevant models of ARDS[J].Eur Respir J, 2021,58(1):2002978. DOI:10.1183/13993003.02978-2020.
[12] Shah D, Das P, Acharya S, et al. Small immunomodulatory molecules as potential therapeutics in experimental murine models of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS)[J].Int J Mol Sci, 2021,22(5):2573. DOI:10.3390/ijms22052573.
[13] Cui Y, Wang X, Lin F, et al. MiR-29a-3p improves acute lung injury by reducing alveolar epithelial cell PANoptosis[J].Aging Dis, 2022,13(3):899-909. DOI:10.14336/AD.2021.1023.
[14] An L, Zhao J, Sun X, et al. S-allylmercaptocysteine inhibits mucin overexpression and inflammation via MAPKs and PI3K-Akt signaling pathways in acute respiratory distress syndrome[J].Pharmacol Res, 2020,159:105032. DOI:10.1016/j.phrs.2020.105032.
[15] 刘文萍, 王忠芝, 宋以宁. 科研成果转化为课堂教学案例的探索与实践[J].计算机教育,2019(8):146-149. DOI:10.3969/j.issn.1672-5913.2019.08.035.
[16] 张军香, 董韶鹏, 袁梅, 等. 科研课题向实验教学的转化模式研究[J].实验技术与管理,2010,27(5):18-22. DOI:10.3969/j.issn.1002-4956.2010.05.006.
