Under the background of building new medical education, it is an important link for the national health development strategy to cultivate innovative talents who are competent to adapt to the needs of the times. Ophthalmology, as a discipline focusing on visual organ diseases and highly dependent on the development of engineering technology, is in urgent need of ophthalmic medical-engineering interdisciplinary talents. At present, there are some problems in the cultivation of ophthalmic medical-engineering interdisciplinary talents, including insufficient depth of interdisciplinary integration, unclear educational path, and unsophisticated talent cultivation mode. The Ophthalmology Department of the Ninth People′s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, based on the school′s concept of excellent medical innovative talents with multi-disciplinary medical and industrial skills, had explored the educational path for such talents from the aspects of the establishment of medicine-engineering interdisciplinary innovation training base, interdisciplinary teaching team building, and constructing ″one body with two wings″ education model, in order to provide reference for promoting the cultivation of high-level interdisciplinary talents in the affiliated hospitals of medical colleges in China.