Objective To explore the effect of small private online course (SPOC) in clinical skill integration training. Methods Experimental control method was used in this study. From September 2016 to June 2018, 248 five-year program students majoring in clinical medicine enrolled in 2013 and 2014 in Shanxi Medical University were selected as the research objects. The students in each grade were randomly divided into experimental group and the control group. The experimental group adopted the SPOC of clinical skills integration training mode, while the control group adopted the traditional single skill theory education combined with on-site demonstration training mode. The training outcomes of the two model groups were evaluated by the pass rate in the first stage of clinical fundamental skills stage I test of National Medical Licensing Examination and by the pass rate of the skill test of National Medical Licensing Examination and by the questionnaire survey results. Results The passing rates of the first stage I of National Medical Licensing Examination in the experimental groups of 2013 and 2014 [95.0% (57/60), 93.5% (58/62)] were significantly higher than those in the control group [83.9% (52/62), 81.3% (52/64)] (all P<0.05); the passing rate of the skill test of National Medical Licensing Examination in the experimental group of 2013 [98.3% (59/60)] was also significantly higher than that in the control group [87.1% (54/62)] (P< 0.05); the satisfaction rates of the students about their training mode in the experimental and control group were 90.6% (774/854) and 81.6% (720/882) respectively, and the differences were statistically significant (P<0.05). Conclusions The teaching model of clinical skill integration based on SPOC is helpful to improve students' clinical skill level and clinical thinking ability, which is recognized by students.