Objective T o explore the new tutorial system based on C(conceive), D(design), I(implement) and O(operate) (CDIO) applied in dental resident standardization for creation ability. Methods Residents from Department of Stomatology, Union Hospital, Tongji Medical College, HUST starting training in 2016 and 2017 that were chosen with 16 in experimental group and 16 in control group. CDIO based tutorial system and regular administration were applied separately to evaluate ability of study, creation and operation by questionnaire and exams. Results There was no statistically significant on the total score of study ability assessment between experiment group (201.06±9.77) and the control one (189.63±21.32) (t=1.95,P=0.06). However, the score on time administration and information processing of experimental group was significantly higher than that in control group[(26.69±3.07) vs (23.94±3.66)][(26.43±2.73) vs (23.25±3.28)][(t=2.30,P=0.03),(t=3.15,P=0.01)]. Innovation ability in experimental group (48.13±8.14) was significantly higher than that of control group (40.56±1.36) (t=3.67, P<0.01). There were no statistically significant between groups in theory and operation score (all P>0.05). Conclusions This model may improve the innovation capacity of trainees.