Objective Evaluation the effect of the “specific disease group model” in critical care medicine teaching.Methods When the 36 students joining our department of Critical Care Medicine of Shanghai General Hospital, they were divided into two groups: the experiment group and the control group(12 of experiment group and 24 of control group), to do the one month clinical practice. When they finished the practice, they took tests, gave lecture and answered the questionnaire to receive the evaluation of the practice. After they finished the whole year practice, we calculated the papers, subjects and rewards the students got, to evaluate the research ability of the students according to the group they belonged to.Results There were no statistic deference of exam results within the two groups(t=1.737, P＞0.05). But the students of the experiment group did better than the control group students in lecture, questionnaire, paper writing and subject application.Conclusions The “specific disease group” model had superiority in training the students' clinical thinking, self-study ability and research ability, compared to the regular group. Meanwhile , the students in the “specific disease group” had the better experience of clinic work, interest and satisfaction.