Objective To explore the application effect of intelligent online virtual training system combined with flipped classroom teaching method in basic clinical skills teaching.Methods The study used the experimental control method.The study lasted from September to December 2018.The subjects of this study were 87 students majoring in clinical medicine in the eight-year program from grade 2014 of West China School of Medicine,Sichuan University.They were randomly divided into experiment group (44) and control group (43).The experimental group adopted intelligent online virtual training system combined with flipped classroom teaching method,and the control group adopted traditional teaching method.The teaching content was 4 basic clinical skill projects,including pleural puncture,abdominal puncture,lumbar puncture and bone marrow puncture.The evaluation method was carried out by comparing the students' performance and a self-designed questionnaire was used to investigate the students' evaluation of the teaching method.Results The test scores of total scores in the experimental group (90.56±6.56) were all higher than those in the control group (82.69±8.64)(t=4.79,P<0.01).The experimental group believed that the intelligent online virtual training system combined with flipped classroom teaching method was superior to the traditional teaching method in terms of improving classroom learning efficiency,enhancing self-learning ability,improving skill proficiency,enhancing clinical operation confidence (all P<0.01).Conclusions The teaching process of the intelligent online virtual training system combined with the flipped classroom teaching method is conducive to improving the efficiency of classroom teaching,cultivating students' self-learning ability,enhancing students' willingness to learn.