Objective To explore the effect of task-oriented flipped class(TFC) in residency training during “Internet plus” era. Methods The experimental control method was used.In July 2019, a total of 74 residents who received standardized training in the department of infection of Changhai Hospital of the Naval Medical University were included. They were divided into TFC group and traditional class(TC) group. The scores of basic theory, clinical skills,daily performance and the results of questionnaire survey were used to evaluate the teaching effectiveness and satisfaction. Results The total score of TFC group was significantly higher than that of TC Group[(208.47±4.58) vs (202.05±5.18),(81.35±2.79) vs (79.57±3.47),(84.38±3.34) vs (80.77±3.50), (42.74±1.44) vs (41.71±1.61), all P<0.05].The results showed that the TFC group has the most significant improvement in self-learning ability, communication and expression ability and humanistic quality(0.671 vs 0.431,0.750 vs 0.472,0.566 vs 0.319).Conclusions “Internet plus” era task oriented flip classroom helps to improve the theoretical and practical teaching effect and students' comprehensive ability, and it is highly evaluated by students.