Objectives To evaluate the wisdom teaching tool Rain Classroom in the learning of pathophysiology.Methods Questionnaire survey was used in this study. In 2018, 96 students majoring in five-year clinical medicine in grade 2016 of Fujian Medical University were selected. The first 7 chapters of the course were taught by the traditional lecture style and the last 6 chapters was taught by Rain Classroom. After the course, the questionnaire survey result was used to evaluate the students' recognition of Rain Classroom and the learning outcomes of Rain Classroom.Results Compared with the traditional lecture style, 85.4%(82/96)of the students choose Rain Classroom, 93.8%(90/96)of them believe Rain Classroom is helpful for learning,72.9% (70/96) of the students think that Rain Classroom is helpful to activate the classroom atmosphere, 64.6%(62/96)of the students think that Rain Classroom is helpful to improve the efficiency in class, 97.9% (94/96) of the students think that the red envelopes for answering questions can stimulate the learning.Conclusions The Rain Classroom teaching mode can not only construct an active learning an atmosphere to improve the efficiency learning,, but also stimulate the learning. This result is meaningful and need to be shared by faculty in medical schools.