Nephrology is an important part in clinical medicine, for which renal pathology plays an auxiliary role. Exploring suitable teaching methods to combine nephrology and renal pathology content is expected to improve the teaching effect. This study selected the nephrology knowledge required to mastered in the syllabus, collected the clinical and pathological data of typical cases by digital section scanning system, recorded teaching videos and uploaded them to the cloud to build an integrated platform of nephrology and renal pathology. The Small Private Online Course (SPOC) teaching based on the integrated platform was performed on 110 students majored in five-year clinical medicine of Grade 2018 in the Second Xiangya Hospital of Central South University. A follow-up test (10 points) and a questionnaire survey were used to evaluate the teaching effect. The experimental students scored well in the classroom test [10.0(9.0,10.0)]. The result showed that 98.2% (108/110) of students reckoned this teaching mode helps improve independent learning ability, 87.3% (96/110) of students reckoned it increases the interest in learning, and 100.0% (110/110) of students reckoned it helps to understand and consolidate the therapeutic knowledge and deepen memories. The SPOC teaching mode based on the integrated platform of nephrology and renal pathology is helpful to improve the learning ability and interest of undergraduate students of clinical medicine and enhance the effectiveness of nephrology internship teaching.