Case-based learning and bedside teaching are both important methods to cultivate clinical thinking and active learning ability of medical students. Under the traditional teaching mode, there is a problem that theoretical knowledge is out of touch with clinical practice in critical care medicine teaching. The Department of Critical Care Medicine of Tianjin Medical University General Hospital adopted the model of case-based learning combined with bedside teaching for 30 undergraduates majoring in anesthesiology in the five-year clinical medicine of grade 2020, built a clinical case library for undergraduate teaching of critical care medicine, designed 7 sessions of case-based learning integrated with core theoretical knowledge, two of which trained students' practical skills through simulated teaching and 2 times of bedside teaching were arranged. The course assessment results showed that the average score of students' regular performance was 88.63 points, the average score of the final exam was 77.53 points, and among them, the average score of the comprehensive case analysis questions was 32.93 points. The results of the questionnaire survey showed that 26 students (86.7%) believed that the case-based learning combined with bedside teaching model was helpful to deepen the understanding and application of theoretical knowledge; 29 (96.7%) believed that the teaching model was helpful to cultivate clinical thinking and the ability to solve clinical problem; 28 (93.3%) believed that this teaching model was helpful to enhance the ability of independent learning and communication and cooperation. Case-based learning combined with bedside teaching model is helpful to the undergraduate teaching of critical care medicine, which has been recognized by students and is worthy of further promotion.