This article reviews the training model of the Doctor of Medicine (MD) program at Duke-NUS Medical School (Duke-NUS) in Singapore based on the field research findings. The MD program at Duke-NUS aims to cultivate outstanding clinicians with diversification potential of ″med+ X″, which is composed of four modules: clinical professional course module, clinical practice training module, research ability training module, and comprehensive professionalism training module. The clinical professional course module primarily adopts an integrated curriculum teaching model, introducing the team based learning teaching method. The clinical practice training module consists of four stages: fundamentals of clinical practice: clinical clerkship, advanced clinical rotation and student-in -practice, embody the characteristics of early exposure to clinical practice and adequate clinical training. The research ability training module focuses on concentrated research training based on research methodology-related courses. The comprehensive professionalism training module runs throughout the program, assisting students in preparing for safe medical practice at various stages of academic growth. The MD program at Duke-NUS has developed a comprehensive curriculum and improved teaching method. Its successful experience can serve as a basis and reference for the reform of medical education model and the cultivation of medical compound talents in China.