Objective To examine the effect of job satisfaction on knowledge team innovativeness among medical school faculty and to test the mediating role of perceived organizational equity in the relationship between job satisfaction and knowledge team innovativeness. Methods From September 1 to September 30, 2021, 561 teachers from four medical colleges and universities in Heilongjiang Province were selected as survey subjects through a stratified convenient sampling method through online questionnaire survey,and investigated their sense of perceived organizational justice,job satisfaction and knowledge team innovation ability.The data were analyzed by means of a web-based questionnaire using descriptive statistics, Pearson correlation coefficient, and bias-corrected percentile Bootstrap method. Results The job satisfaction score of medical school teachers is (3.73±0.93), the perceived organizational fairness score is (4.15±0.94), and the knowledge team innovation ability score is (4.89±1.04).The job satisfaction of medical school teachers is positively correlated with organizational fairness and knowledge team innovation ability (r values of 0.604 and 0.547, both P<0.01); Job satisfaction positively predicts the innovation ability of knowledge teams, with a standardized direct effect of 0.187, accounting for 30.106% of the total effect. The standardized mediating effect of perceived organizational fairness between job satisfaction and knowledge team innovation ability is 0.435, accounting for 69.894% of the total effect. Conclusions The job satisfaction of medical school teachers has a positive effect on the innovation ability of knowledge teams, and perceived organizational fairness has a significant mediating effect between job satisfaction and knowledge team innovation ability.