The standardized residency training is centered on clinical skills and clinical thinking, but the demand for training the ability of clinical research for residents is becoming increasingly prominent. Traditional clinical research classroom teaching has problems such as boring content, outdated mode, and insufficient practice. In order to improve the clinical research practice ability of residents, the Fifth People′s Hospital of Shanghai, Fudan University launched clinical research interest group teaching in residency training in March 2022 to February 2023. This article introduced the teaching objectives, modules, forms, and organization of the interest group approach, and evaluated the teaching effectiveness through questionnaire surveys and clinical research design reviews. The evaluation results showed that all 22 residents participating in the clinical research interest group teaching were satisfied with the teaching activity and believed that the teaching would improve the clinical research practice and self-learning ability. The clinical research interest group teaching embodied the concept of student-centered teaching, and helped to improve the quality of residency cultivation.