Case-based learning (CBL) is important in developing students′ critical thinking and problem solving skills, while students were less likely to be exposed to sufficient and systematic clinical scenarios in traditional didactic lectures. This study utilized the blended teaching mode based on standard clinical cases in oral and maxillofacial oncology course. Via online teaching platform system, online modules and traditional face-to-face lectures were combined, allowing integration of case-based learning method into lectures-based and problem-based learning (PBL) teaching system. The questionnaire survey results showed that out of 83 students participating in teaching reform, compared to traditional teaching mode, 65(78.3%) believed that the blended teaching mode based on standard clinical cases increased learning efficiency; 73(88.0%) believed that this teaching mode facilitated development of critical thinking and problem solving skills. The teaching practice results indicated that this teaching mode is helpful for the theoretical learning of oral and maxillofacial oncology course and can be further promoted.