Exploring the curriculum-based political and virtual awareness elements embedded into the otorhinolaryngology course helps guide students to establish a correct outlook on life and values and cultivate a sense of social responsibility. In this study, 96 students majoring in clinical medicine enrolled in 2019 and 32 students majoring in forensic medicine enrolled in 2019 of Sun Yat-sen University were recruited, the practice and exploration of political and virtual awareness education carried out by the faculty of Otorhinolaryngology of the Third Affiliated Hospital of Sun Yat-sen University were expounded. The teaching effect is assessed through the evaluation of lecturers' trial lectures by senior supervisors before class and the survey of students' satisfaction about the element of political and virtual awareness after class. The results showed that the supervisory evaluation results of all five teachers were all excellent. More than 85% of clinical medicine and forensic medicine students are satisfied with the overall design of the political and virtual awareness element in curriculum, cases to improve learning interest, to improve humanistic literacy, to enhance teamwork, and to help understand professional norms, and integrating such element with professional course content. And there was no statistically significant difference in the evaluation results of political and virtual awareness in the curriculum [for example, in terms of the overall design of ideological and political education in the curriculum, 92 (95.8%) and 30 (93.8%) students expressed satisfaction respectively, P=1.000]. The teachers have good instructing abilities in the course, and the political and virtual awareness element in the otolaryngology science course has been recognized by students from different majors. Students are relatively satisfied with the political and virtual awareness in the otolaryngology science course.