Objective To explore the application of problem-based learning (PBL) combined with case-based learning (CBL) teaching method in the course of pharmaceutical management. Method The test control method was used. From February to September in 2021 and 2022, A total of 73 undergraduate students majoring in pharmacy enrolled in 2018 and 2019 of Wuhan University were selected as the research participants. Among them, 33 students in grade 2019 were selected as the experimental group, using PBL combined with CBL teaching method, while 40 students in grade 2018 were selected as the control group, using traditional teaching methods. The results of examination and questionnaire were used to evaluate the teaching effect. T-test and chi-square test were used for statistical analyses. Results The overall test scores of theoretical knowledge in the experimental group were significantly higher than that in the control group [(95.08±2.30) vs.(90.06±2.85), P=0.002], and the score of comprehensive use of knowledge in the experimental group was higher than that in the control group [(43.80±1.38) vs. (38.04±4.04),P<0.001]. The results of the questionnaire survey showed that the score of students in the experimental group on the overall satisfaction was higher than that in the control group [(96.43±7.45) vs. (66.38±10.07),P＜0.001]. Conclusions The application of PBL combined with CBL teaching method in the teaching of pharmaceutical management will help improve students′ theoretical knowledge assessment results and comprehensive knowledge application score, improve overall satisfaction, and improve the teaching quality of pharmaceutical management.