Objective To explore the teaching effect of flipped classroom teaching method based on small private online courses (SPOC) in child health care courses. Methods This is an experimental study. In February 2022, 85 students in grade 2019 of “5+3” integrated pediatric major of clinical medicine in Xinjiang Medical University were selected as the research participants. Including 42 students in class 1 as the experimental group, taught by ″SPOC+ flipped classroom″ teaching method, and 43 students from class 2 as the control group, taught by traditional teaching methods. The teaching effect was evaluated by the final examination result and questionnaire survey. T-test was used for comparison between groups. Results There were statistically significant differences between the experimental group and the control group in their usual scores [(92.1±5.8) vs. (78.7±7.5)], theoretical examination scores [(86.2±10.7) vs. (68.5±12.4)] and comprehensive scores [(89.2±7.8) vs. (72.4±5.9)] (all P<0.001). The results of the questionnaire survey showed that the proportion of students in the experimental group in increased interest in course content [34 (81.0%) vs. 21 (48.8%)], improved clinical thinking ability [36 (85.7%) vs. 10( 23.3%)], enhanced independent learning ability[31(73.8%) vs. 12( 27.9%)] and improved teamwork ability [31 (73.8%) vs. 11 ( 25.6%)] were higher than those in the control group, the differences were statistically significant (all P < 0.001). Conclusions The flipped classroom blended teaching method based on SPOC helps to improve students' test scores, increase students' interest in child health care course, improve students' various abilities and has been recognized by students.