The teaching method based on ″rain classroom + BOPPPS″ aims to motivate students' learning and is helpful to cultivate students' comprehensive ability. Taking the digestive system of human anatomy as an example, the design and implementation of ″rain classroom + BOPPPS″ teaching method was assessed in human anatomy for ″5+3″ integrated clinical medicine major involving in 52 students in Harbin Medical University, and the teaching effect was evaluated by final exam and questionnaire survey ways. Results showed that the mean score of final exam was (82.7±7.6), 8 students (15.4%) received excellent score (≥90 points), and all 52 students (100.0%) passed the exam(≥60 points). In addition, in this teaching 47 students (90.4%) completed pre-class tasks by myself before class, all 52 students (100.0%) passed the pre-assessment and post-assessment, 49 students (94.2%) took actively participation in the process of teaching, 51 students (98.1%) considered that this teaching method was helpful to improve the learning interest and cultivate the autonomous learning ability in their learning, and 50 students (96.2%) believed that this teaching method could promote their ability to analyze and solve problems. In summary, ″rain classroom + BOPPPS″ teaching method can promote students to participate in the whole teaching process, improve their interest in learning and self-learning ability, which ultimately resulting in a good teaching effect. Additionally, this method also can significantly develop the analyzing and problem-solving ability of students.