Postgraduates with master′s degree in nursing are the backbone of nursing service in the future. Their humanities training is directly related to the quality of clinical nursing service. However, at present, the curriculum of nursing postgraduates in many schools in China lacks a humanities/psychology curriculum module featuring clinical practice. This paper puts forward the curriculum framework of clinical practice of psychological nursing and makes practical exploration. Teaching objective of this course was to improve the postgraduate students′ abilities in the nurse-patient communication, humanistic care, narrative nursing, and system intervention. The course content integrated the theoretical and practical content of modules such as nurse-patient communication, Balint group, narrative nursing, palliative care, family intervention and group intervention. The teaching methods combined case teaching, experiential teaching, role-playing and other methods. Students reported that their clinical practice ability was improved. The course also provided a feasible model for the cultivation of clinical skills of psychological nursing. Therefore, it seems beneficial of integrating the training of clinical skills of psychological nursing into the standardized training curriculum system.