Research-based teaching is characterized by problem setting and then penetrating the teaching content into problem solving process through research performance and has been increasingly used in experiment course. This research took the experiment course of basic toxicology of 7-year program undergraduates majoring in preventive medicine enrolled in 2017 in Peking University as an example. The teaching effect and satisfaction with the mode were evaluated by scores of examination and questionnaire survey. The examination results showed that the excellentratewas76.4%(68/89).Totally 79.8%(71/89)of the students were satisfied with this mode and. 66.3%(59/89)of students believed that it helped them to establish teamwork spirit. Research-based teaching mode applied in experiment course of toxicology showed a good effectiveness, which improves the student's research capacity in terms of logic pathway.