Objective To evaluate the effect of application of intelligent mobile terminal combined with quick response code in anesthesia practice teaching. Methods Totally 26 undergraduate students majoring in anesthesiology enrolled in 2016 from Fujian Medical University were randomly divided into experimental group and control group with 13 in each. The experimental group scanned the code of training database for information at any time during anesthesia practice training as required and participated in clinical practice according to routine procedures, while the control group only participated in clinical practice in a conventional way. At the end of practice training, the theoretical examination, case simulation assessment and questionnaire survey were used to evaluate the effects of different teaching methods. Results The scores of the theoretical examination and the case simulation assessment in experimental group were higher [(82.46±9.61) vs. (71.69±7.10), (78.38±5.08) vs. (72.85±4.02)]than those in control group(P<0.05). Compared with the students in control group, the autonomous learning capacity and the effect of practice training of students in experimental group was higher [8.00(8.00, 10.00) vs. 8.00(6.00, 8.00), 8.00(8.00, 10.00) vs. 8.00(7.00, 8.00), (P<0.05)]. Conclusions The intelligent mobile terminal combined with quick response code applied in anesthesia practice training improves the quality of training and the autonomous learning capacity of students.