Objective To explore the teaching effect of task-driven teaching method based on WeChat platform applied to ophthalmology probation. Methods From September to November 2020, 354 students majoring in clinical medicine of dalian Medical University were selected as subjects, including 128 students from 2017 as experimental group and 226 students from 2016 as control group. The experimental group adopted task-driven teaching method based on wechat platform, while the control group adopted traditional teaching method. Through written test, actual practice, students and teachers questionnaire, teaching supervision evaluation comprehensive evaluation of the teaching effect. Results The results of the experimental group in written test were better than those of the control as shown by pass rate [91.6%(118/128) vs. 74.3%(168/226)], average score [(84.32±2.24) vs. (68.26±3.12)]. The passing rate in practical operation of experimental group was 95.7%(122/128), average score was (90.72±2.76).There were 83.6%(107/128) of the experimental students agreed that the new teaching mode stimulated their interest in ophthalmology, 93.0%(119/128) believed that the new teaching mode strengthened their learning outcomes of the course concerned, and 85.1%(109/128) believed that the new teaching mode promoted independent learning. According to questionnaire survey in faculty, 12 teachers believed that experimental students' self-learning before class, students' timely feedback and communication after class, and 13 teachers believed that the method created active learning atmosphere in classroom. On the basis of affirming teachers' teaching attitude and capacity, the new teaching mode is considered to be able to enrich the teaching content, mobilize the classroom atmosphere and improve the teaching effect (total score 90.25±3.55). Conclusions The task-driven teaching method based on WeChat platform has improved students' probationary performance and practical operation ability, also been widely recognized by teachers and students, which is effective, sustainable and popularizing.