According to the needs of COVID-19 epidemic prevention and control, Stomatological College of Nanjing Medical University carried out a new online teaching, based on the National Online Open Courses and was supported by a Virtual Interactive Network Teaching Platform and others. The teaching effect was evaluated by comparing the examination results of students in two grades and questionnaire survey in July 2020. Among the five-year students, 2016 students' scores of oral implantology were higher than those of 2015[(87.47±7.67) vs. (84.76±5.16), P<0.05]. Students under "5+3" integration training system, 2016 students' scores of oral surgery were higher than those of 2015[(80.73±4.52) vs. (73.94±10.63), P<0.01]. The survey results showed that the content and form of online teaching were generally accepted by students. Students were able to well understand the professional courses with high degree of satisfaction. Good teaching effect has been obtained through the application of online teaching. Meanwhile, there are also some problems needed to be solved urgently with extensive application of this method. Our online teaching practice provides some ideas and experience for the comprehensive application of the online as well as offline teaching methods of stomatology education, and also puts forward new strategy extensive application of this hybrid mode.